Czech J. Anim. Sci., 2011, 56(1):30-36 | DOI: 10.17221/341/2009-CJAS

Effect of dietary antibacterial peptide and zinc-methionine on performance and serum biochemical parameters in piglets

J.H. Wang, C.C. Wu, J. Feng
Department of Bioengineering College, Institute of Medicinal Chemistry, Chongqing University, Chongqing, P.R. China

The objective of this study was to evaluate the effect of dietary supplementation of antibacterial peptide and zinc methionine on performance and some serum biochemical parameters of weaned piglets. Rongchang male piglets (28 days of age, initial weight 8.4 ± 0.65 kg) were used. All piglets were randomly allotted to four diets including the control group, the antibacterial peptide (AP) group containing 10 mg antibacterial peptide/kg diet, the zinc methionine (Zn-Met) group with 1 200 zinc methionine/kg diet (equal to 200 mg Zn2+/kg diet), the zinc methionine/antibacterial peptide (Zn/AP) group containing 10 mg antibacterial peptide and 1 200 mg zinc methionine/kg diet, respectively, in a 4-week feeding experiment. Each of these groups consisted of six replications with 8 pigs per replication. Average daily gain (ADG) and average daily feed intake (ADFI) both improved in the antibacterial peptide group (P < 0.05, P < 0.05), zinc methionine group (P < 0.05, P < 0.05) and zinc methionine/antibacterial peptide group (P < 0.01, P < 0.05), as compared with the control. Dietary zinc methionine also significantly reduced the diarrhoea ratio of piglets (P < 0.05). The serum immunoglobulin G (IgG) and superoxide dismutase (SOD) were increased (P < 0.05) and total cholesterol (TC) decreased (P < 0.05) in the antibacterial peptide group and zinc-methionine group, the high density lipoprotein (HDL) increased (P < 0.05) in the zinc methionine group, as compared with the control. The results indicated that antibacterial peptide and zinc methionine were effective in improving growth performance, enhancing immune function, blood vessel function and antioxidant enzyme activity of piglets.

Keywords: antimicrobial peptide; zinc amino acid; growth performance; serum indexes; weaned piglets

Published: January 31, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Wang JH, Wu CC, Feng J. Effect of dietary antibacterial peptide and zinc-methionine on performance and serum biochemical parameters in piglets. Czech J. Anim. Sci. 2011;56(1):30-36. doi: 10.17221/341/2009-CJAS.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Ahn S.H., Um J.S., Kim D.H., Paik I.H. (1998): Effects of the sources and levels of supplemental zinc on the performance of weanling pigs. Korean Journal of Animal Science, 40, 9-12.
    2. Alexandra K.M., William J.G., Robert E.W.H. (2006): Antibacterial peptides for therapeutic use obstacles and realistic outlook. Current Opinion in Pharmacology, 6, 468-472. Go to original source... Go to PubMed...
    3. Allan F.J., Thompson K.G., James K.A.C., Manktelow B.W., Koolaard J.P., Johnson R.N., McNutt P.V. (2001): Serum lipoprotein cholesterol and triglyceride concentrations in pigs fed diets containing fish oil, milkfat, olive oil and coconut oil. Nutrition Research, 21, 785-795. Go to original source...
    4. Broom L.J., Miller H.M., Kerr K.G., Knapp J.S. (2006): Effects of zinc oxide and Enterococcus faecium SF68 dietary supplementation on the performance, intestinal microbiota and immune status of weaned piglets. Research in Veterinary Science, 80, 45-54. Go to original source... Go to PubMed...
    5. Brown J.A., Clinc T.R. (1974): Urea excretion in pigs: an indicator of quality and amino acid requirements. The Journal of Nutrition, 104, 542-545. Go to original source... Go to PubMed...
    6. Caine W.R., Metzler-Zebeli B.U., McFall M., Miller B., Ward T.L., Kirkwood R.N., Mosenthin R. (2009): Supplementation of diets for gestating sows with zinc amino acid complex and gastric intubation of suckling pigs with zinc-methionine on mineral status, intestinal morphology and bacterial translocation in lipopolysaccharide-challenged early-weaned pigs. Research in Veterinary Science, 86, 453-462. Go to original source... Go to PubMed...
    7. Cheng J., Kornegay E.T., Schell T. (1998): Influence of dietary lysine on the utilization of zinc from zinc sulphate and zinc lysine complex by young pigs. Journal of Animal Science, 76, 1064-1074. Go to original source... Go to PubMed...
    8. Eggum B.O. (1970): Blood urea measurement as a technique for assessing protein quality. British Journal of Nutrition, 24, 983-988. Go to original source... Go to PubMed...
    9. Hoskin D.W., Ramamoorthy A. (2008): Studies on anticancer activities of antimicrobial peptides. Biochimica et Biophysica Acta, 1778, 357-375. Go to original source... Go to PubMed...
    10. Howard D.H. (2004): Resistance-induced antibiotic substitution. Health Economics, 13, 585-595. Go to original source... Go to PubMed...
    11. Jin Z., Yang Y.X., Choi J.Y., Shinde P.L., Yoon S.Y., Hahn T.W., Lim H.T., Park Y.K., Hahm K.S., Joo J.W., Chae B.J. (2008): Effects of potato (Solanum tuberosum L. cv. Golden valley) protein having antimicrobial activity on the growth performance, and intestinal microflora and morphology in weanling pigs. Animal Feed Science and Technology, 140, 139-154. Go to original source...
    12. Marianne J.W., Melin L., Lindberg R., Johannisson A., Petersson L., Wallgren P. (1998): Dietary zinc oxide in weaned pigs - effects on performance, tissue concentrations, morphology, neutrophil functions and faecal microflora. Research in Veterinary Science, 64, 225-231. Go to original source... Go to PubMed...
    13. Nicolas P., Mor A. (1995): Peptides as weapons against microorganisms in the chemical defense system of vertebrates. Annual Review of Microbiology, 49, 277-304. Go to original source... Go to PubMed...
    14. Qiang C.K., Yang Z.F., Zhao W.Y. (2004): Molecular structure, functional mechanism and its application of defensins of insects. China Animal Health, 01, 33-35.
    15. Revy P.S., Jondreville C., Dourmad J.Y., Nys Y. (2004): Effect of zinc supplemented as either an organic or an inorganic source and of microbial phytase on zinc and other minerals utilisation by weanling pigs. Animal Feed Science and Technology, 116, 143-155. Go to original source...
    16. Storici P., Scocchi M., Tossi A., Gennaro R., Zanetti M. (1994): Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA. FEBS Letters, 337, 303-307. Go to original source... Go to PubMed...
    17. Sun K., Zou X.T. (2008): Research progress of antibacterial peptides and its application in livestock husbandry. Gansu Animal and Veterinary Sciences, 38, 43-46.
    18. Timothy P.B., John B.B., Jonathan C., John D., Paul A.K., Stephen G.P., David I.R. (2008): New cyclic peptides via ring-closing metathesis reactions and their antibacterial activities. Tetrahedron, 64, 11270-11290. Go to original source...
    19. Wang L.X., Wang Z.H., Lu W.C., You F. (2003): Effect of supplementation of zinc oxide or Zn-methionine on performance and biochemical parameters of blood in the piglets. Journal of Animal and Veterinary Science, 35, 21-22.
    20. Wang Y.Z., Xu C.L., An Z.H., Liu J.X., Feng J. (2008): Effect of dietary bovine lactoferrin on performance and antioxidant status of piglets. Animal Feed Science and Technology, 140, 326-336. Go to original source...
    21. Wen L.F., Zhang C.M., Fu L., Bi Y.Z. (2001): Applied effects of antimicrobial peptide in replace of antibiotic in weanling pigs' retion. China Feed, 18, 13-14.
    22. Wu W.P. (2007): Effect of different zinc sources and levels on performance and blood physio-chemistry indexes of weanling pigs. Hunan Agriculture University, Hunan, China.
    23. Yu H.M., Wang J.F., Chen B.J. (2008): Effect of new antimicrobial peptides on performance of weaning piglets. Feed and Husbandry, 9, 39-41.
    24. Zhang C., Chen D.W., Ding X.M., Kuang S.Y., Tang L. (2005): The effect of zinc amino acid chelate on the performance of weaning pigs. Journal of Sichuan Agricultural University, 23, 490-494.

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content