Czech J. Anim. Sci., 2015, 60(12):557-563 | DOI: 10.17221/8598-CJAS

Effects of feed intake restriction during late pregnancy on maternal metabolic changes and fetal development in ewesOriginal Paper

C.Z. Zhang1, Y.C. Liu2,3, F. Gao1
1 College of Animal Science, Inner Mongolia Agricultural University, Hohhot, P.R. China
2 College of Life Science, Inner Mongolia Agricultural University, Hohhot, P.R. China
3 Inner Mongolia Key Laboratory of Biomanufacturing, Hohhot, P.R. China

This study investigated the effects of feed intake restriction during late pregnancy on maternal metabolic changes and fetal development in ewes. Six ewes out of 35 Mongolian ewes were slaughtered at the beginning of the experiment and the remaining 29 animals were allocated to three different groups: Restricted Group 1 (RG1; 0.175 MJME BW-0.75/day, n = 12), Restricted Group 2 (RG2; 0.33 MJME BW-0.75/day, n = 9), and Control Group (CG; ad libitum, 0.67 MJME BW-0.75/day, n = 8). At 140 days (d) of gestation, 6 representative ewes from each group were slaughtered. The results indicated the maternal net body weight loss, the concentrations of glucose (GLU) (120 d), GLU (140 d), total amino acid (TAA) (140 d), total protein (TP) (140 d), albumin (ALB) (140 d), and globulin (GLB) (140 d) were significantly (P < 0.01) decreased, while those of nonesterified fatty acid (NEFA) (120 d), NEFA (140 d), β-hydroxybutyric acid (BHBA) (120 d), and BHBA (140 d) in maternal plasma were greatly enhanced in RG1 group compared to CG group (P < 0.01). For RG2 group, a significant decrease of the maternal net body weight loss (P < 0.01) and the concentrations of GLU (140 d) (P < 0.01), TAA (140 d) (P < 0.01), ALB (140 d) (P < 0.01), GLB (140 d) (P < 0.05), and a significant increase of NEFA (120 d) (P < 0.05) and NEFA (140 d) (P < 0.01) in maternal plasma were found in relation to CG group. Furthermore, the fetal weight was significantly reduced in RG1 and RG2 groups (P < 0.01), and body length (P < 0.05), thoracic girth (P < 0.05), thoracic depth (P < 0.05), abdomen circumference (P < 0.05), straighted crown-rump length (P < 0.01), and curved crown-rump length (P < 0.01) in RG1 group were also decreased compared to CG group. With the decrease of nutrient level during late pregnancy, the maternal protective buffer system in RG2 group still played a major role, but the system in RG1 group might have been destroyed, which resulted in serious impacts on the fetal growth and development.

Keywords: Mongolian ewes; nutrition level; late gestation; physiological metabolism; fetal growth

Published: December 31, 2015  Show citation

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Zhang CZ, Liu YC, Gao F. Effects of feed intake restriction during late pregnancy on maternal metabolic changes and fetal development in ewes. Czech J. Anim. Sci. 2015;60(12):557-563. doi: 10.17221/8598-CJAS.
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    References

    1. Barker D.J.P. (1999): The long-term outcome of retarded fetal growth. Schweizerische Medizinische Wochenschrift, 129, 189-196. Go to PubMed...
    2. Chilliard Y., Bocquier F., Doreau B.M. (1998): Digestive and metabolic adaptations of ruminants to undernutrition and consequence on reproduction. Reproduction Nutrition Development, 38, 131-152. Go to original source... Go to PubMed...
    3. Gao F., Hou X.Z., Liu Y.C. (2007): Effect of hormonal status and metabolic changes of restricted ewes during late pregnancy on their fetal growth and development. Science in China, Series C: Life Sciences, 50, 766-772. Go to original source... Go to PubMed...
    4. Gao F., Liu Y.C., Hou X.Z. (2009): Effect of maternal undernutrition during late pregnancy on growth and development of ovine fetal visceral organs. Asian-Australasian Journal of Animal Sciences, 22, 1633-1639. Go to original source...
    5. Gluckman P.D., Hanson M.A. (2004): Developmental origins of disease paradigm: a mechanistic and evolutionary perspective. Pediatric Research, 56, 311-317. Go to original source... Go to PubMed...
    6. Gluckman P.D., Cutfield W., Hofman P., Hanson M.A. (2005): The fetal, neonatal and infant environments - the long-term consequences for disease risk. Early Human Development, 81, 51-59. Go to original source... Go to PubMed...
    7. Hanson M., Godfrey K.M., Lillycrop K.A., Burdge G.C., Gluckman P.D. (2011): Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms. Progress in Biophysics and Molecular Biology, 106, 272-280. Go to original source... Go to PubMed...
    8. Ingelfinger J.R., Nuyt A.M. (2012): Impact of fetal programming, birth weight, and infant feeding on later hypertension. The Journal of Clinical Hypertension, 14, 365-371. Go to original source... Go to PubMed...
    9. Langley-Evans S.C., McMullen S. (2010): Developmental origins of adult disease. Medical Principles and Practice, 19, 87-98. Go to original source... Go to PubMed...
    10. Lekatz L.A., Wu G., Caton J.S., Taylor J.B., Reynolds L.P., Redmer D.A., Vonnahme K.A. (2011): Maternal selenium supplementation and timing of nutrient restriction in pregnant sheep: impacts on nutrient availability to the fetus. Journal of Animal Science, 89, 59-76. Go to original source... Go to PubMed...
    11. Limesand S.W., Rozance P.J., Smith D., Hay Jr. W.W. (2007): Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction. American Journal of Physiology - Endocrinology and Metabolism, 293, E1716-E1725. Go to original source... Go to PubMed...
    12. Louey S., Cock M.L., Stevenson K.M., Harding R. (2000): Placental insufficiency and fetal growth restriction lead to postnatal hypotension and altered postnatal growth in sheep. Pediatric Research, 48, 808-814. Go to original source... Go to PubMed...
    13. Maritz G.S., Cock M.L., Louey S., Suzuki K., Harding R. (2004): Fetal growth restriction has long-term effects on postnatal lung structure in sheep. Pediatric Research, 55, 287-295. Go to original source... Go to PubMed...
    14. McMillen I.C., Adams M.B., Ross J.T., Coulter C.L., Simonetta G., Owens J.A., Robinson J.S., Edwards L.J. (2001): Fetal growth restriction: adaptations and consequences. Reproduction, 122, 195-204. Go to original source... Go to PubMed...
    15. Micke G.C., Sullivan T.M., Magalhaes R.J.S., Rolls P.J., Norman S.T., Perry V.E.A. (2010): Heifer nutrition during early- and mid-pregnancy alters fetal growth trajectory and birth weight. Animal Reproduction Science, 117, 1-10. Go to original source... Go to PubMed...
    16. Osgerby J.C., Wathes D.C., Howard D., Gadd T.S. (2002): The effect of maternal undernutrition on ovine fetal growth. Journal of Endocrinology, 173, 131-141. Go to original source... Go to PubMed...
    17. Redmer D.A., Wallace J.M., Reynolds L.P. (2004): Effect of nutrient intake during pregnancy on fetal and placental growth and vascular development. Domestic Animal Endocrinology, 27, 199-217. Go to original source... Go to PubMed...
    18. Regnault T.R., de Vrijer B., Galan H.L., Wilkening R.B., Battaglia F.C., Meschia G. (2007): Development and mechanisms of fetal hypoxia in severe fetal growth restriction. Placenta, 28, 714-723. Go to original source... Go to PubMed...
    19. Reynolds L.P., Caton J.S., Redmer D.A., Grazul-Bilska A.T., Vonnahme K.A., Borowicz P.P., Luther J.S., Wallace J.M., Wu G., Spencer T.E. (2006): Evidence for altered placental blood flow and vascularity in compromised pregnancies. Journal of Physiology, 572, 51-58. Go to original source... Go to PubMed...
    20. Robinson J.J., Sinclair K.D., McEvoy T.G. (1999): Nutritional effects on fetal growth. Animal Science, 68, 315-331. Go to original source...
    21. Su H., Wang Y., Zhang Q., Wang F., Cao Z., Aziz-ur-Rahman M., Cao B., Li S. (2013): Responses of energy balance, physiology, and production for transition dairy cows fed with a low-energy prepartum diet during hot season. Tropical Animal Health and Production, 45, 1495-1503. Go to original source... Go to PubMed...
    22. Symonds M.E., Budge H., Stephenson T., McMillen I.C. (2001): Fetal endocrinology and development - manipulation and adaptation to long-term nutritional and environmental challenges. Reproduction, 121, 853-862. Go to original source... Go to PubMed...
    23. Visentin S., Grisan E., Zanardo V., Bertin M., Veronese E., Cavallin F., Ambrosini G., Trevisanuto D., Cosmi E. (2013): Developmental programming of cardiovascular risk in intrauterine growth-restricted twin fetuses according to aortic intima thickness. Journal of Ultrasound in Medicine, 32, 279-284. Go to original source... Go to PubMed...
    24. Wang J.D., Li J.P., Zhang J.F., Hao J.H., Liang Z.X., Guo Y.H. (2004): Effect of betaine on broiler product performance and fat metabolism in different stage supplement. Chinese Journal of Veterinary Science, 24, 87-90.
    25. Wu G., Bazer F.W., Wallace J.M., Spencer T.E. (2006): Intrauterine growth retardation: implications for the animal sciences. Journal of Animal Science, 84, 2316-2337. Go to original source... Go to PubMed...
    26. Ye J., Zheng R., Wang Q., Liao L., Ying Y., Lu H., Cianflone K., Ning Q., Luo X. (2012): Downregulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growth. Pediatric Research, 72, 550-559. Go to original source... Go to PubMed...
    27. Zhang K.C., Tan X. (2007): Progress in the study of nutritional manipulation of NEFA in periparturient dairy cows. Journal of Dairy Science and Technology, 29, 149-152.

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