Czech J. Anim. Sci., 2021, 66(6):189-199 | DOI: 10.17221/167/2020-CJAS
Iodine concentration in milk and human nutrition: A reviewReview
- 1 Department of Veterinary Sciences, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture, Nitra, Slovak Republic
- 2 Research Institute for Animal Production Nitra, National Agricultural and Food Centre, Lužianky, Slovak Republic
- 3 Department of Animal Husbandry Sciences, Faculty of Agriculture, University of South Bohemia in České Budějovice, České Budějovice, Czech Republic
The aim of the review was to provide information about the importance of iodine in human nutrition and to review milk as an important source of iodine, and also to summarize the main factors affecting iodine concentration in milk. Iodine is an essential element for the thyroid gland function and synthesis of thyroid hormones, which regulate key processes of metabolism, brain development and growth. Therefore, it is important to ensure adequate, neither deficient nor excessive, intake of this element in animal nutrition, but more importantly in the nutrition of humans. Milk and dairy products are very valuable sources of iodine. However, its concentration in milk is very variable, as it is affected by many different factors - iodine intake in feed, antinutritional factors, iodine species (forms) used for feeding, animal keeping, farm management and possibly also milk yield. Additionally, milk iodine concentration is also affected by teat dipping with iodine disinfection, and by milk processing (e.g. skimming and heat treatment). All these aforementioned factors may possibly play their role in improving human nutrition, especially the nutrition of pregnant, lactating women, and people on a low-salt diet who are the most vulnerable to insufficient iodine intake.
Keywords: iodine content; dairy animals; dairy products; feeds; factors; supplementation
Published: May 30, 2021 Show citation
References
- Abt E, Spungen J, Pouillot R, Gamalo-Siebers M, Wirtz M. Update on dietary intake of perchlorate and iodine from U.S. food and drug administration's total diet study: 2008- 2012. J Expo Sci Environ Epidemiol. 2018 Jan;28(1):21-30.
Go to original source...
Go to PubMed...
- Arrizabalaga JJ, Jalon M, Espada M, Canas M, Latorre PM. Iodine concentration in ultra-high temperature pasteurized cow's milk. Applications in clinical practice and in community nutrition. Med Clin. 2015 Jul 20;145(2):55-61.
Go to original source...
- Bath SC, Button S, Rayman MP. Iodine concentration of organic and conventional milk: Implications for iodine intake. Br J Nutr. 2012 Apr;107(7):935-40.
Go to original source...
Go to PubMed...
- Battaglia M, Moschini M, Giuberti G, Gallo A, Piva G, Masoero F. Iodine carry over in dairy cows: Effects of levels of diet fortification and milk yield. Ital J Anim Sci. 2010 Jan 1;8(Suppl. 2):262-4.
Go to original source...
- Brito AF. Assessing the potential of milk iodine intake to mitigate iodine deficiency in pregnant women of the United States via supplementation of Ascophyllum nodosum meal to dairy cows: A sensitivity analysis. J Dairy Sci. 2020 Aug 1;103(8):6798-809.
Go to original source...
Go to PubMed...
- Carlsen MH, Andersen LF, Dahl L, Norberg N, Hjartaker A. New iodine food composition database and updated calculations of iodine intake among Norwegians. Nutrients. 2018 Jul 20;10(7): 13 p.
Go to original source...
Go to PubMed...
- Castro SI, Lacasse P, Fouquet A, Beraldin F, Robichaud A, Berthiaume R. Feed iodine concentrations on farms with contrasting levels of iodine in milk. J Dairy Sci. 2011 Sep 1;94(9):4684-9.
Go to original source...
Go to PubMed...
- Castro SI, Berthiaume R, Robichaud A, Lacasse P. Effects of iodine intake and teat-dipping practices on milk iodine concentrations in dairy cows. J Dairy Sci. 2012 Jan 1; 95(1):213-20.
Go to original source...
Go to PubMed...
- Commission Regulation (EC) No 1459/2005 of 8 September 2005 amending the conditions for authorisation of a number of feed additives belonging to the group of trace elements. OJEU 2005 Sep 9;L233: 3 p.
- Coneyworth LJ, Coulthard LCHA, Bailey EH, Young SD, Stubberfield J, Parsons L, Saunders N, Watson E, Homer EM, Welham SJM. Geographical and seasonal variation in iodine content of cow's milk in the UK and consequences for the consumer's supply. J Trace Elem Med Biol. 2020 May 1;59: 9 p.
Go to original source...
Go to PubMed...
- Flachowsky G. Iodine in animal nutrition and iodine transfer from feed into food of animal origin. Lohmann Information. 2007 Oct;42(2):47-59.
- Flachowsky G, Schone F, Leiterer M, Bemmann D, Spolders M, Lebzien P. Influence of an iodine depletion period and teat dipping on the iodine concentration in serum and milk of cows. J Anim Feed Sci. 2007;16(1):18-25.
Go to original source...
- Flachowsky G, Franke K, Meyer U, Leiterer M, Schone F. Influencing factors on iodine content of cow milk. Eur J Nutr. 2014 Mar 1;53(2):351-65.
Go to original source...
Go to PubMed...
- Franke K, Meyer U, Wagner H, Flachowsky G. Influence of various iodine supplementation levels and two different iodine species on the iodine content of the milk of cows fed rapeseed meal or distillers dried grains with solubles as the protein source. J Dairy Sci. 2009 Sep;92(9):4514-23.
Go to original source...
Go to PubMed...
- GfE - German Society of Nutrition Physiology. Empfehlungen zur Energie- und Nahrstoffversorgung der Ziegen No. 9 [Recommendations for Supply of Energy and Nutrients to Goats Report No. 9]. Frankfurt am Main (DE): DLG Verlag; 2003. 121 p. German.
- Grace ND, Waghorn GC. Impact of iodine supplementation of dairy cows on milk production and iodine concentrations in milk. N Z Vet J. 2005 Feb 1;53(1):10-3.
Go to original source...
Go to PubMed...
- Grau G, Aguayo A, Vela A, Aniel-Quiroga A, Espada M, Miranda G, Martinez-Indart L, Martul P, Castano L, Rica I. Normal intellectual development in children born from women with hypothyroxinemia during their pregnancy. J Trace Elem Med Biol. 2015 Jul 1;31:18-24.
Go to original source...
Go to PubMed...
- Haldimann M, Alt A, Blanc A, Blondeau K. Iodine content of food groups. J Food Compost Anal. 2005 Sep 1; 18(6):461-71.
Go to original source...
- Hanus O, Vorlicek Z, Sojkova K, Rozsypal R, Vyletelova M, Roubal P, Gencurova V, Pozdisek J, Landova H. A comparison of selected milk indicators in organic herds with conventional herd as reference. Folia Vet. 2008;52(3-4):155-9.
- Hanus O, Kucera J, Yong T, Chladek G, Holasek R, Trinacty J, Gencurova V, Sojkova K. Effect of sires on wide scale of milk indicators in first calving Czech Fleckvieh cows. Arch Anim Breed. 2011 Oct 10;54(1):36-50.
Go to original source...
- Hejtmankova A, Kuklik L, Trnkova E, Dragounova H. Iodine concentrations in cow's milk in Central and Northern Bohemia. Czech J Anim Sci. 2006 May 1;51(5):189-95.
Go to original source...
- Iannaccone M, Ianni A, Elgendy R, Martino C, Giantin M, Cerretani L, Dacasto M, Martino G. Iodine supplemented diet positively affect immune response and dairy product quality in Fresian cow. Animals. 2019 Nov;9(11): 13 p.
Go to original source...
Go to PubMed...
- Johner S, Nida K, Jahreis G, Remer T. Aktuelle Untersuchungen zeitlicher Trends und saisonaler Effekte des Jodgehaltes in Kuhmilch - Untersuchungen aus Nordrhein Westfalen = Time trends and seasonal variation of iodine content in German cow's milk - investigations from Northrhine-Westfalia. Berl Munch Tierarztl Wochenschr. 2012 Jan-Feb;125(1-2):76-82. German with English abstract.
- Konecny R, Krizova Z, Hladky J, Kautska J, Hasonova L, Samkova E, Libalova K, Travnicek J. Iodine content development in raw cow's milk in three regions of the Czech Republic between the years 2008 and 2018. Acta Vet Brno. 2019 Oct 9;88(3):265-70.
Go to original source...
- Kroupova V, Herzig I, Kursa J, Travnicek J, Ther R. Saturace krav jodem v Ceske republice [Iodine saturation of cows in the Czech Republic]. Veterinarstvi. 2001 Nov; 51:155-8. Czech.
- Kursa J, Herzig I, Travnicek J, Kroupova V. Milk as a food source of iodine for human consumption in the Czech Republic. Acta Vet Brno. 2005;74(2):255-64.
Go to original source...
- Laurberg P, Cerqueira CH, Ovesen L, Rasmussen LB, Perrild H, Andersen S, Pedersen IB, Carle A. Iodine intake as a determinant of thyroid disorders in populations. Best Pract Res Clin Endocrinol Metab. 2010 Feb 1;24(1):13-27.
Go to original source...
Go to PubMed...
- Lazarus J. Iodine status in Europe in 2014. Eur Thyroid J. 2014 Mar;3(1):3-6.
Go to original source...
Go to PubMed...
- Miseikiene R, Tusas S, Biziene R, Kerziene S, Micinski J, Matusevicius P. Influence of teat disinfection with iodine preparation on bacterial contamination of teats, hygienic quality and content of iodine in milk. J Elem. 2020;25(1):225-36.
- Mullan K, McKeever E, Hamill L, Doolan K, Young I, Smyth P, Flynn A, Patterson CH, Walton J, Meharg A, Graham U, McMullan P, Mccance D, Bell M, McHugh C, McQuaid S, Tuthill A, Black N, O'Loughlin A, Woodside J. Iodine status on the Island of Ireland [abstract]. In: Endocrine abstracts; 2017 Nov 6-8; Harrogate, United Kingdom. Bristol (UK): Bioscientifica Ltd; 2017. p. 181.
Go to original source...
- Norouzian MA. Iodine in raw and pasteurized milk of dairy cows fed different amounts of potassium iodide. Biol Trace Elem Res. 2011 Feb;139(2):160-7.
Go to original source...
Go to PubMed...
- Norouzian MA, Azizi F. Factors affecting iodine content in dairy cow's milk - a review. Eur J Food Res Rev. 2013 May 3;3(2):63-73.
- NRC - National Research Council. Nutrient requirements of sheep. 6th rev. ed. Washington, DC: National Academy Press; 1985. 100 p.
- Nudda A, Battacone G, Decandia M, Acciaro M, AghiniLombardi F, Frigeri M, Pulina G. The effect of dietary iodine supplementation in dairy goats on milk production traits and milk iodine content. J Dairy Sci. 2009 Oct 1; 92(10):5133-8.
Go to original source...
Go to PubMed...
- O'Kane M, Pourshahidi K, Mulhern M, Weir R, Hill S, O'Reilly J, Kmiotek D, Ward-Deitrich CH, Mackle E, Fitzgerald E, Lowis C, Johnston M, Strain JJ, Yeates A. The effect of processing and seasonality on the iodine and selenium concentration of cow's milk produced in Northern Ireland (NI): Implications for population dietary intake. Nutrients. 2018 Mar 1;10(3): 14 p.
Go to original source...
Go to PubMed...
- Ovadia YS, Chris Sabastian C, Dahl L, Troen AM, Mabjeesh SJ. The effect of iodophor post-milking teat disinfection on iodine content in goat milk. Isr J Vet Med. 2018 Dec 1; 73(4):14-22.
- Paulikova I, Seidel H, Nagy O, Kovac G. Milk iodine content in Slovakia. Acta Vet Brno. 2008;77(4):533-8.
Go to original source...
- Payling LM, Juniper DT, Drake C, Rymer C, Givens DI. Effect of milk type and processing on iodine concentration of organic and conventional winter milk at retail: Implications for nutrition. Food Chem. 2015 Jul 1;178:327-30.
Go to original source...
Go to PubMed...
- Pearce EN. Iodine nutrition: Recent research and unanswered questions. Eur J Clin Nutr. 2018 Sep;72(9):1226-8.
Go to original source...
Go to PubMed...
- Rasmussen LB, Larsen EH, Ovesen L. Iodine content in drinking water and other beverages in Denmark. Eur J Clin Nutr. 2000 Jan;54(1):57-60.
Go to original source...
Go to PubMed...
- Rey-Crespo F, Miranda M, Lopez-Alonso M. Essential trace and toxic element concentrations in organic and conventional milk in NW Spain. Food Chem Toxicol. 2013 May 1;55:513-8.
Go to original source...
Go to PubMed...
- Rezaei Ahvanooei MR, Norouzian MA, Hedayati M, Vahmani P. Effect of potassium iodide supplementation and teat-dipping on iodine status in dairy cows and milk iodine levels. Domest Anim Endocrinol. 2021 Jan 1;74: 5 p.
Go to original source...
Go to PubMed...
- Roseland JM, Phillips KM, Patterson KY, Pehrsson PR, Bahadur R, Ershow AG, Somanchi M. Large variability of iodine content in retail cow's milk in the U.S. nutrients. 2020 May;12(5): 16 p.
Go to original source...
Go to PubMed...
- SCF - Scientific Committee on Food. Opinion of the Scientific Committee on Food on the tolerable upper intake level of iodine. Brussels (Belgium): European Commision - Health and Consumer Protection DirectorateGeneral; 2002 Oct 7. 25 p.
- Schirone M, Tofalo R, Perpetuini G, Manetta AC, Di Gianvito P, Tittarelli F, Battistelli N, Corsetti A, Suzzi G, Martino G. Influence of iodine feeding on microbiological and physico-chemical characteristics and biogenic amines content in a raw ewes' milk cheese. Foods. 2018 Jul 7;7(7): 11 p.
Go to original source...
Go to PubMed...
- Schone F, Rajendram R. Iodine in farm animals. In: Preedy VR, Burrow GN, Watson R, editors. Comprehensive handbook of iodine: Nutritional, biochemical, pathological and therapeutic aspects. Amsterdam (NL): Academic Press; 2009. p. 151-70.
Go to original source...
- Schone F, Sporl K, Leiterer M. Iodine in the feed of cows and in the milk with a view to the consumer's iodine supply. J Trace Elem Med Biol. 2017 Jan 1;39:202-9.
Go to original source...
Go to PubMed...
- Stevenson MC, Drake C, Givens DI. Further studies on the iodine concentration of conventional, organic and UHT semi-skimmed milk at retail in the UK. Food Chem. 2018 Jan 15;239:551-5.
Go to original source...
Go to PubMed...
- Travnicek J, Kursa J. Iodine concentration in milk of sheep and goats from farms in South Bohemia. Acta Vet Brno. 2001;70(1):35-42.
Go to original source...
- Travnicek J, Kroupova V, Soch M. Iodine content in bulk feeds in western and southern Bohemia. Czech J Anim Sci. 2004;49(11):483-8.
Go to original source...
- Travnicek J, Herzig I, Kursa J, Kroupova V, Navratilova M. Iodine content in raw milk. Vet Med-Czech. 2006;51 (9):448-53.
Go to original source...
- Travnicek J, Kroupova V, Konecny R, Stankova M, Stastna J, Hasonova L, Mikulova M. Iodine status in ewes with the intake of iodine enriched alga Chlorella. Czech J Anim Sci. 2010 Feb 18;55(2):58-65.
Go to original source...
- Travnicek J, Kroupova V, Dusova H, Krhovjakova J, Konecny R. Optimalizace obsahu jodu v kravskem mlece [Optimization of iodine content in cow's milk]. Ceske Budejovice (Czech Republic): Jihoceska univerzita v Ceskych Budejovicich; 2011. 55 p. Czech.
- Troan G, Dahl L, Meltzer HM, Abel MH, Indahl UG, Haug A, Prestlokken E. A model to secure a stable iodine concentration in milk. Food Nutr Res. 2015 Jan 1;59(1): 9 p.
Go to original source...
Go to PubMed...
- van der Reijden OL, Zimmermann MB, Galetti V. Iodine in dairy milk: Sources, concentrations and importance to human health. Best Pract Res Clin Endocrinol Metab. 2017 Aug 1;31(4):385-95.
Go to original source...
Go to PubMed...
- van der Reijden OL, Galetti V, Hulmann M, Krzystek A, Haldimann M, Schlegel P, Manzocchi E, Berard J, Kreuzer M, Zimmermann MB, Herter-Aeberli I. The main determinants of iodine in cows' milk in Switzerland are farm type, season and teat dipping. Br J Nutr. 2018 Mar; 119(5):559-69.
Go to original source...
Go to PubMed...
- van der Reijden OL, Galetti V, Herter-Aeberli I, Zimmermann MB, Zeder C, Krzystek A, Haldimann M, Barmaz A, Kreuzer M, Berard J, Schlegel P. Effects of feed iodine concentrations and milk processing on iodine concentrations of cows' milk and dairy products, and potential impact on iodine intake in Swiss adults. Br J Nutr. 2019 Jul 24;122(2):172-85.
Go to original source...
Go to PubMed...
- Vorlova L, Hodulova L, Borkovcova I, Pridalova H, Kostrhounova R, Klimesova-Vyletelova M, Sustova K. Iodine content in bulk tank milk samples in relation to dairy farm size. Acta Vet Brno. 2014;83(10):S9-13.
Go to original source...
- Walther B, Wechsler D, Schlegel P, Haldimann M. Iodine in Swiss milk depending on production (conventional versus organic) and on processing (raw versus UHT) and the contribution of milk to the human iodine supply. J Trace Elem Med Bio. 2018 Mar 1;46:138-43.
Go to original source...
Go to PubMed...
- WHO - World Health Organization. Assessment of iodine deficiency disorders and monitoring their elimination. Geneva (Switzerland): World Health Organization; 2007. 97 p.
- Zimmermann MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: A review. Am J Clin Nutr. 2009 Feb 1;89(2 Suppl.):668S-672S.
Go to original source...
Go to PubMed...
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