Czech J. Anim. Sci., 2015, 60(4):164-170 | DOI: 10.17221/8130-CJAS

Effect of prolonged aflatoxin B1 administration on blood serum oestradiol-17β and progesterone concentrations of goats during the anoestrus period --Original Paper

G.D. Kourousekos1, E.K. Theodosiadou2, A.G. Lymberopoulos3, S. Belibasaki4, C. Boscos1
1 Faculty of Veterinary Medicine, Aristotle University, Thessaloniki, Greece
2 Faculty of Veterinary Medicine, University of Thessaly, Karditsa, Greece
3 Department of Animal Production, Alexander Technological Educational Institute, Thessaloniki, Greece
4 Veterinary Research Institute, Ηellenic Agricultural Organization Demeter, Thessaloniki, Greece

The effect of prolonged aflatoxin B1 (AFB1) administration on blood serum oestradiol-17β and progesterone concentrations in goats during the anoestrus period was investigated. Thirty Greek indigenous goats were used; 10 goats received, per os, 50 μg (treated group T50) and 10 goats received 100 μg (treated group T100) AFB1/day/head, respectively, for 31 days, while 10 goats served as controls (C). Blood samples were collected from each goat twice a week to determine serum oestradiol-17β and progesterone concentrations by radioimmunoassay. Multiple linear regression analysis revealed a significant (P < 0.05) positive dependence of blood serum oestradiol-17β concentration over group (C = 0, T50 = 50, T100 = 100), in a dose-dependent manner, and a significant (P < 0.05) negative dependence over time (0-31 days, from the onset to the end of AFB1 administration). Linear regression analysis revealed a significant (P < 0.05) positive dependence of blood serum progesterone concentration over group (C = 0, T50 = 50, T100 = 100), in a dose-dependent manner. Pearson's correlation coefficient revealed a significant (P < 0.05) positive correlation between blood serum oestradiol-17β and progesterone concentration, but only in the goats of the control group. In conclusion, the prolonged administration of 100 or even of 50 μg AFB1/day/head during the anoestrus period, increased blood serum oestradiol-17β and progesterone concentrations of goats, in a dose-dependent manner, and in the treated groups disturbed the positive correlation between oestradiol-17β and progesterone concentration shown in the goats of the control group.

Keywords: aflatoxins; mycotoxins; ovarian steroids; small ruminants; anoestrus

Published: April 30, 2015  Show citation

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Kourousekos GD, Theodosiadou EK, Lymberopoulos AG, Belibasaki S, Boscos C. Effect of prolonged aflatoxin B1 administration on blood serum oestradiol-17β and progesterone concentrations of goats during the anoestrus period --. Czech J. Anim. Sci. 2015;60(4):164-170. doi: 10.17221/8130-CJAS.
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