Czech J. Anim. Sci., 2014, 59(9):416-427 | DOI: 10.17221/7653-CJAS

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of ratsOriginal Paper

V. Vlčková1, M. Malinová1, B. Koubková1, J. Száková1, V. Zídek2, A. Fučíková1, J. Zídková3, D. Kolihová1, P. Tlustoš1
1 Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic
2 Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
3 Faculty of Food and Biochemical Technology, Institute of Chemical Technology Prague, Prague, Czech Republic

The long-term accumulation of risk elements (As, Cd, Pb) originated from differently contaminated soils in rat organism was investigated during a model two-generation experiment. The effect of soil contamination level, gender, and length of exposure as well as the interactions between risk elements and selected essential macro- and microelements were studied. Rat diet contained 10% of individual soils (based on dry weight): (i) Fluvisol heavily polluted by As, Cd, Zn, and Pb, (ii) Luvisol contaminated by As, Cd, and Zn, and (iii) uncontaminated Chernozem. Male and female Wistar rats used for the experiment were housed in cages in a room with controlled temperature for 60 days and were fed ad libitum the mentioned diets. Subsequently, the pregnant females were continuously fed the experimental diet until weaning when the young animals were separated to male and female and fed the experimental diet till day 110 of age. The element contents in rat tissues reflected the risk element contents in contaminated soils. The bioaccessibility and bioavailability of the risk elements decreased in the order Cd>As>Pb and was affected by the soil physicochemical parameters. No significant differences were observed between male and female rats as well as between the first and the second generation. However, interactions were reported among the risk elements where the high cadmium content in Fluvisol resulted in increasing arsenic accumulation in the rat liver. Moreover, arsenic-copper interactions were observed where significant increase of the copper level was determined in kidney of the animals fed Luvisol exceeding 50-fold the maximum permissible limits for As content in agricultural soils. Among the hematological and biochemical characteristics of rats, total erythrocyte count (Er), hematocrit (Hct) increased confirming adverse effect of soil-derived risk elements especially in male rats.

Keywords: Keywords: risk elements; soil; soil ingestion; liver; kidney; blood; Rattus norvegicus

Published: September 30, 2014  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Vlčková V, Malinová M, Koubková B, Száková J, Zídek V, Fučíková A, et al.. Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats. Czech J. Anim. Sci. 2014;59(9):416-427. doi: 10.17221/7653-CJAS.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Adachi K., Dote T., Dote E., Mitsui G., Kono K. (2007): Strong acute toxicity, severe hepatic damage, renal injury and abnormal serum electrolytes after intravenous administration of cadmium fluoride in rats. Journal of Occupational Health, 49, 235-241. Go to original source... Go to PubMed...
    2. Amaral A., Cabral C., Guedes C., Rodrigues A. (2007): Apoptosis, metallothionein, and bioaccessible metals in domestic mice (Mus musculus L.) from a human-inhabited volcanic area. Ecotoxicology, 16, 475-481. Go to original source... Go to PubMed...
    3. Asagba S.O. (2010): Comparative effect of water and foodchain mediated cadmium exposure in rats. Biometals, 23, 961-971. Go to original source... Go to PubMed...
    4. Bencko V., Cikrt M., Lener J. (1995): Toxic Metals in Life and Work Environment of People. Grada, Prague, Czech Republic. (in Czech)
    5. Bhadauria S., Flora S.J.S. (2007): Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats. Cell Biology and Toxicology, 23, 91-104. Go to original source... Go to PubMed...
    6. Birri P.N.R., Perez R.D., Cremonezzi D., Perez C.A., Rubio M., Bongiovanni G.A. (2010): Association between As and Cu renal cortex accumulation and physiological and histological alterations after chronic arsenic intake. Environmental Research, 110, 417-423. Go to original source... Go to PubMed...
    7. Borgese L.P., Brandao R., Godoi B., Nogueira C.W., Zeni G. (2008): Oral administration of diphenyl diselenide protects against cadmium-induced liver damage in rats. Chemico-Biological Interactions, 171, 15-25. Go to original source... Go to PubMed...
    8. Castro B.H., Padilla L.M.D., Bustamante M.S., Rocha D., Perez M.D.O., Capdeville M.E.J., Perez D.P.P., Stephano A.Q., Amaro R.G. (2009): Effect of arsenic on regulatory T cells. Journal of Clinical Immunology, 29, 461-469. Go to original source... Go to PubMed...
    9. Chmielnicka J., Sowa B., (1996): Cadmium interaction with essential metals (Zn, Cu, Fe), metabolism metallothionein, and ceruloplasmin in pregnant rats and fetuses. Ecotoxicology and Environmental Safety, 35, 277-281. Go to original source... Go to PubMed...
    10. Cui X., Okayasu R. (2008): Arsenic accumulation, elimination, and interaction with copper, zinc and manganese in liver and kidney of rats. Food and Chemical Toxicology, 46, 3646-3650. Go to original source... Go to PubMed...
    11. Dudley R.E., Svoboda D.J., Klaassen C.D. (1982): Acute exposure to cadmium causes severe liver injury in rats. Toxicology and Applied Pharmacology, 65, 302-313. Go to original source... Go to PubMed...
    12. El-Demerdash F.M., Yousef M.I., Kedwany F.S., Baghdadi H.H. (2004): Cadmium induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene. Food and Chemical Toxicology, 42, 1563-1571. Go to original source... Go to PubMed...
    13. Ellickson K.M., Meeker R.J., Gallo M.A., Buckley B.T., Lioy P.J. (2001): Oral bioavailability of lead and arsenic from a NIST standard reference soil material. Archives of Environmental Contamination and Toxicology, 40, 128-135. Go to original source... Go to PubMed...
    14. Fischer A.B., Georgieva R., Nikolova V., Halkova J., Bainova A., Hristeva V., Penkov D., Alandjiisk D. (2003): Health risk for children from lead and cadmium near a non-ferrous smelter in Bulgaria. International Journal of Hygiene and Environmental Health, 206, 25-38. Go to original source... Go to PubMed...
    15. Fucikova A., Slamova A., Szakova J., Cibulka J., Heger J. (1995): The influence of dietary cadmium on hematological parameters and phagocytic activity of leukocytes in rats. Živočišná výroba, 40, 15-18. (in Czech)
    16. Fucikova A., Kozakova H., Slamova A., Cibulka J. (1996): The influence of dietary cadmium on hematological parameters and disaccharidase activities in rat jejunal enterocytes. Živočišná výroba, 41, 63-67. (in Czech)
    17. Hettiarachchi G.M., Pierzynski G.M., Oehme F.W., Sonmez O., Ryan J.A. (2003): Treatment of contaminated soil with phosphorus and manganese oxide reduces lead absorption by Sprague-Dawley rats. Journal of Environmental Quality, 32, 1335-1345. Go to original source... Go to PubMed...
    18. Hiratsuka H., Katsuta O., Toyota N., Tsuchitani M., Umemura T., Marumo F. (1996): Chronic cadmium exposureinduced renal anemia in ovariectomized rats. Toxicology and Applied Pharmacology, 137, 228-236. Go to original source... Go to PubMed...
    19. Hochadel J.F., Waalkes M.P. (1997): Sequence of exposure to cadmium and arsenic determines the extent of toxic effects in male Fisher rats. Toxicology, 116, 89-98. Go to original source... Go to PubMed...
    20. Jankovska I., Vadlejch J., Szakova J., Miholova D., Kunc P., Knizkova I., Cadkova Z., Langrova I. (2010): Experimental studies on the cadmium accumulation in the cestode Monienzia expansa (Cestoda: Anoplocephalidae) and its final host (Ovis aries). Experimental Parasitology, 126, 130-134 Go to original source... Go to PubMed...
    21. Karadas C., Kara D. (2011): In vitro gastro-intestinal method for the assessment of heavy metal bioavailability in contaminated soils. Environmental Science and Pollution Research, 18, 620-628. Go to original source... Go to PubMed...
    22. Kataranovski M., Kataranovski D., Savic D., Jovcic G., Bogdanovic Z., Jovanovic T. (1998): Granulocyte and plasma cytokine activity in acute cadmium intoxication in rats. Physiological Research, 47, 453-461.
    23. Kostic M.M., Ognjanovic B., Dimitrijevic S., Zikic R.V., Stajn A., Rosic G.L., Zivkovic R.V. (1993): Cadmiuminduced changes of antioxidant and metabolic status in red-blood cells of rats - in-vivo effects. European Journal of Haematology, 51, 86-92. Go to original source... Go to PubMed...
    24. Kusakabe T., Nakajima K., Suzuki K., Nakazato K., Takada H., Satoh T., Oikawa M., Kobayashi K., Koyama H., Arakawa K., Nagamine T. (2008): The changes of heavy metal and metallothionein distribution in testis induced by kadmium exposure. Biometals, 21, 71-81. Go to original source... Go to PubMed...
    25. Marin A.R., Masscheleyn P.H., Patrick Jr. W.H. (1993): Soil redox-pH stability of arsenic species and its influence on arsenic uptake by rice. Plant and Soil, 152, 245-253. Go to original source...
    26. Matovic V., Buha A., Bulat Z., Dukic-Cosic D. (2011): Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium. Arhiv za Higijenu Rada i Toksikologiju, 62, 65-76. Go to original source... Go to PubMed...
    27. Mehlich A. (1984): Mehlich 3 Soil Test Extractant: A modification of Mehlich 2 Extractant. Communications in Soil Science and Plant Analysis, 15, 1409-1416. Go to original source...
    28. Noble R.R.P., Hough R.M., Watkins R.T. (2010): Enrichment and exposure assessment of As, Cr and Pb of the soils in the vicinity of Stawell, Victoria, Australia. Environmental Geochemistry and Health, 32, 193-205. Go to original source... Go to PubMed...
    29. Ognjanovic B.I., Pavlovic S.Z., Maletic S.D., Zikic R.V., Stajn A.S., Radojicic R.M., Saicic Z.S., Petrovic V.M. (2003): Protective influence of vitamin E on antioxidant defence system in the blood of rats treated with cadmium. Physiological Research, 52, 563-570. Go to original source...
    30. Oktem F., Arslan M.K., Dundar B., Delibas N., Gultepe M., Ilhan I.E. (2004): Renal effects and erythrocyte oxidative stress in long-term low-level lead-exposed adolescent workers in auto repair workshops. Archives of Toxicology, 78, 681-687. Go to original source... Go to PubMed...
    31. Palacios J., Roman D., Cifuentes F. (2012): Exposure to low level of arsenic and lead in drinking water from Antofagasta city induces gender differences in glucose homeostasis in rats. Biological Trace Element Research, 148, 224-231. Go to original source... Go to PubMed...
    32. Paul P.C., Misbahuddin M., Nasimuddin Ahmed A.N., Dewan Z.F., Mannan N.A. (2002): Accumulation of arsenic in tissues of iron-deficient rats. Toxicology Letters, 135, 193-197. Go to original source... Go to PubMed...
    33. Prigge E., Baumert H.P., Muhle H. (1977): Effects of dietary and inhalative cadmium on hemoglobin and hematocrit in rats. Bulletin of Environmental Contamination and Toxicology, 17, 585-590. Go to original source... Go to PubMed...
    34. Pruvot C., Douay F., Herve F., Waterlot C. (2006): Heavy metals in soil, crops and grass as a source of human exposure in the former mining areas. Journal of Soils and Sediments, 6, 215-220. Go to original source...
    35. Renugadevi J., Prabu S.M. (2010): Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Experimental and Toxicologic Pathology, 62, 171-181. Go to original source... Go to PubMed...
    36. Ruby M.V., Davi A., Schoo R., Eberl S., Sellston C.M. (1996): Estimation of lead and arsenic bioavailability using a physiologically based extraction test. Environmental Science and Technology, 30, 422-430. Go to original source...
    37. Saito S., Yamauchi H., Yoshida K. (2008): Interactions of arsenic with zinc, copper and iron in human hepatic cells. Trace Elements and Electrolytes, 25, 206-210. Go to original source...
    38. Schmolke G., Elsenhans B., Ehtechami C., Forth W. (1992): Arsenic copper interaction in the kidney of the rat. Human and Experimental Toxicology, 11, 315-321. Go to original source... Go to PubMed...
    39. Shan G., Tang T., Zhang X. (2009): The protective effects of ascorbic acid and thiamine supplementation against damage caused by lead in the testes of mice. Journal of Huazhong University of Science and Technology - Medical Sciences, 29, 68-72. Go to original source... Go to PubMed...
    40. Smith Jr. D.M., Mielke H.W., Heneghan J.B. (2008): Subchronic lead feeding study in male rats. Archives of Environmental Contamination and Toxicology, 55, 518-528. Go to original source... Go to PubMed...
    41. Szakova J., Zidek V., Miholova D. (2009): Influence of elevated content of cadmium and arsenic in diet containing feeding yeast on organisms of rats. Czech Journal of Animal Science, 54, 1-9. Go to original source...
    42. Szakova J., Novosadova Z., Zidek V., Fucikova A., Zidkova J., Miholova D., Tlustos P. (2012): The effect of diet amended by risk elements contaminated soil on risk element tissue contents and hematological parameters of rats. Czech Journal of Animal Science, 57, 430-441. Go to original source...
    43. Todorovic T., Dozic I.V.D., Pejovic J., Marjanovic M. (2005): The influence of chronic lead poisoning on the activity of some serum enzymes in rats. Acta Veterinaria, 55, 471-482. Go to original source...
    44. Turgut S., Polat A., Inan M., Turgut G., Emmungil G., Bican M., Karakus T.Y., Genc O. (2007): Interaction between anemia and blood levels of iron, zinc, copper, cadmium and lead in children. Indian Journal of Pediatrics, 74, 827-830. Go to original source... Go to PubMed...
    45. Tzirogiannis K.N., Panoutsopoulos G.I., Demonakou M.D., Hereti R.I., Alexandropoulou K.N., Basayannis A.C., Mykoniatis M.G. (2003): Time-course of cadmium-induced acute hepatotoxicity in the rat liver: the role of apoptosis. Archives of Toxicology, 77, 694-701. Go to original source... Go to PubMed...
    46. Uthus E.O. (2001): High dietary arsenic exacerbates copper deprivation in rats. Journal of Trace Elements in Experimental Medicine, 14, 43-55. Go to original source...
    47. Wang L., Chen D., Wang H., Liu Z. (2009): Effects of lead and/or cadmium on the expression of metallothionein in the kidney of rats. Biological Trace Element Research, 129, 190-199. Go to original source... Go to PubMed...
    48. Whittaker M.H., Wang G., Chen X.-Q., Lipsky M., Smith D., Gwiazda R., Fowler B.A. (2011): Exposure to Pb, Cd, and As mixtures potentiates the production of oxidative stress precursors: 30-day, 90-day, and 180-day drinking water studies in rats. Toxicology and Applied Pharmacology, 254, 154-166. Go to original source... Go to PubMed...
    49. Woods J.S., Fowler B.A. (1977): Effects of chronic arsenic exposure on hematopoietic function in adult mammalian liver. Environmental Health Perspectives, 19, 209-213. Go to original source... Go to PubMed...
    50. Yanez L., Carrizales L., Zanatta M.T., de Jesus Mejia J., Batres L., Diaz-Barriga F. (1991): Arsenic-cadmium interaction in rats: toxic effects in the heart and tissue metal shifts. Toxicology, 67, 227-234. Go to original source... Go to PubMed...
    51. Yu S., Beynen A.C. (2001): High arsenic intake raises kidney copper and lowers plasma copper concentrations in rats. Biological Trace Element Research, 81, 63-70. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content