Czech J. Anim. Sci., 2025, 70(1):33-41 | DOI: 10.17221/59/2024-CJAS

Association between polymorphism within rabbit IGF1 gene and slaughter weight in Termond White rabbitsOriginal Paper

Anna Migdał ORCID...1, Sylwia Ewa Pałka ORCID...1, Michał Kmiecik ORCID...1, Olga Jarnecka ORCID...1, Ewelina Semik-Gurgul ORCID...2, Łukasz Migdał ORCID...1
1 Department of Genetics, Animal Breeding and Ethology, University of Agriculture in Krakow, Krakow, Poland
2 Department of Animal Molecular Biology, National Research Institute of Animal Production, Balice, Poland

Growth traits belong to the most important economic traits in livestock. One of the genes involved in vertebrate growth and development is insulin-like growth factor 1 (IGF1). Therefore, in our study we hypothesised that within the sequence of rabbit IGF1 gene it is possible to identify a polymorphism that may influence growth, carcass or meat traits in rabbits. We identified 6 polymorphisms (g.89259430T>C; g.89259338C>G; g.89259328T>C; 89210029A>G; 89210349C>G and g.89194199C>T) within introns of the IGF1 gene. One polymorphism, g.89194199C>T, was analysed using polymerase chain reaction high-resolution melting (PCR-HRM). We performed the association analysis on 370 animals (males to females 1 : 1) of different breeds: New Zealand White × Flemish Giant crossbreds (NZW × FG), Termond White (TW) and Flemish Giant (FG). Results showed that for growth and slaughter traits in TW populations a significant association (P = 0.003) was found for slaughter weight (SW) when CT genotypes showed significantly higher values compared to CC genotypes (2 878.0 g ± 107.0 and 2 678.0 g ± 34.0, respectively). For TW rabbits we found a significant association (P = 0.009) for dissected bone weight in hind leg (HB) when CT genotypes (127.0 g ± 5.8) had significantly higher values compared to CC genotypes (112.0 g ± 2.4). For carcass traits and physical characteristics of meat we found for musculus longissimus lumborum in TW rabbits that the b* parameter value 45 min after slaughter was significantly higher (P = 0.001) for CT genotypes (1.88 ± 0.05) compared to CC genotypes (0.05 ± 0.02). We conclude that the use of identified SNP in breeding may be limited to some breeds.

Keywords: association analysis; growth traits; insulin like growth factor 1; meat traits oryctolagus cuniculus; SNP

Received: April 23, 2024; Accepted: December 16, 2024; Prepublished online: January 24, 2025; Published: January 30, 2025  Show citation

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Migdał A, Pałka SE, Kmiecik M, Jarnecka O, Semik-Gurgul E, Migdał Ł. Association between polymorphism within rabbit IGF1 gene and slaughter weight in Termond White rabbits. Czech J. Anim. Sci. 2025;70(1):33-41. doi: 10.17221/59/2024-CJAS.
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