Czech J. Anim. Sci., 2024, 69(9):345-355 | DOI: 10.17221/128/2024-CJAS

Changes in the oxidative - biochemical status in dairy cows during the transition period affecting reproductive and health parameters.Review

Jiří Bezdíček1, Andrea Nesvadbová1, Jaromír Ducháček2, Jana Sekaninová3, Luděk Stádník2, Martina Janků3
1 Department of Zoology, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic
2 Department of Animal Science, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic
3 Department of Biochemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic

Negative energy balance (NEB) after calving leads to unique metabolic changes in cows and it provides important information on the period when nutrient output prevails over nutrient intake associated with a number of physiological changes in the organism suitable for detection using biochemical blood analyses. The aim of this paper is to summarise current knowledge of the changes in blood parameters during the period of NEB in relation to non-esterified fatty acids, ketone bodies, and immunologic and stress indicators. The impact of these changes on bovine reproduction and health is also discussed in the sequel. The period of NEB is still a very pertinent area of research as it provides a new insight into connections between physiological systems, to wit, ​​immunology, manifestation of various stress indicators, including oxidative stress, and heat shock proteins inter alia. Understanding the physiological changes during NEB is crucial for successful management of the transition period and subsequent overall good animal health and productivity.

Keywords: health; immunity; ketosis; reproduction; stress

Received: August 2, 2024; Accepted: August 22, 2024; Prepublished online: September 27, 2024; Published: September 30, 2024  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Bezdíček J, Nesvadbová A, Ducháček J, Sekaninová J, Stádník L, Janků M. Changes in the oxidative - biochemical status in dairy cows during the transition period affecting reproductive and health parameters. Czech J. Anim. Sci. 2024;69(9):345-355. doi: 10.17221/128/2024-CJAS.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Aardema H, Gadella BM, van de Lest CH, Brouwers JF, Stout TA, Roelen BA, Vos PL. Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress. J Dairy Sci. 2015 Apr;98(4):2322-36. Go to original source... Go to PubMed...
    2. Aardema H, van Tol HTA, Wubbolts RW, Brouwers JFHM, Gadella BM, Roelen BAJ. Stearoyl-CoA desaturase activity in bovine cumulus cells protects the oocyte against saturated fatty acid stress. Biol Reprod. 2017 May 9;96(5):982-92. Go to original source... Go to PubMed...
    3. Albakova Z, Mangasarova Y. The HSP immune network in cancer. Front Immunol. 2021 Nov 30;12:796493. Go to original source... Go to PubMed...
    4. Aslan N, Yigitarslan K, Buyukoglu T. Investigation of lipid mobilization and oxidative stress parameters in the serum before and after surgery of cows with left displacement abomasum. Inter J Vet Anim Res. 2022 Aug 27;5(2):80-8.
    5. Bach KD, Heuwieser W, McArt JAA. Technical note: Comparison of 4 electronic handheld meters for diagnosing hyperketonemia in dairy cows. J Dairy Sci. 2016 Aug 4;99(11):9136-42. Go to original source... Go to PubMed...
    6. Beran J, Stadnik L, Duchacek J, Okrouhla M, Dolezalova M, Kadlecova V, Ptacek M. Relationships among the cervical mucus urea and acetone, accuracy of insemination timing, and sperm survival in Holstein cows. Anim Reprod Sci. 2013 Nov 1;142(1-2):28-34. Go to original source... Go to PubMed...
    7. Bernabucci U, Ronchi B, Lacetera N, Nardone A. Influence of body condition score on the relationship between metabolic status and oxidative stress in periparturient dairy cows. J Dairy Sci. 2005 Jun 5;88(6):2017-26. Go to original source... Go to PubMed...
    8. Bezdicek J, Makarevich A, Stadnik L, Kubovicova E, Louda F, Hegedusova Z, Holasek R, Duchacek J, Stupka R. Analyse der Effekte, die Menge und die Qualitat der Embryonen in superovulierten Kuhen beeinflussen [Analysis of factors affecting the quantity and quality of embryo production in superovulated cows]. Zuechtungskunde. 2015 Jun 16;87(4):249-64. German.
    9. Bezdicek J, Nesvadbova A, Makarevich A, Kubovicova E. Relationship between the animal body condition and reproduction: The biotechnological aspects. Arch Anim Breed. 2020 Jul 1;63(1):203-9. Go to original source... Go to PubMed...
    10. Bezdicek J, Nesvadbova A, Makarevich A, Kubovicova E. Negative impact of heat stress on reproduction in cows: Animal husbandry and biotechnological viewpoints: A review. Czech J Anim Sci. 2021 Jul 27;66(8):293-301. Go to original source...
    11. Catalani E, Amadori M, Vitali A, Bernabucci U, Nardone A, Lacetera N. The Hsp72 response in peri-parturient dairy cows: Relationships with metabolic and immunological parameters. Cell Stress Chaperones. 2010 Nov 10;15(6):781-90. Go to original source... Go to PubMed...
    12. Codl R, Duchacek J, Vacek M, Pytlik J, Stadnik L, Vrhel M. The influence of eating and rumination time on solids content in the milk and milk yield performance control of cows. Czech J Animal Sci. 2023 Apr 24; 68(4):161-8. Go to original source...
    13. Duchacek J, Stadnik L, Ptacek M, Beran J, Okrouhla M, Citek J, Stupka R. Effect of cow energy status on hypercholesterolemic fatty acids proportion in raw milk. Czech J Food Sci. 2014 Sep 20;32(3):273-9. Go to original source...
    14. Duchacek J, Stadnik L, Ptacek M, Beran J, Okrouhla M, Gasparik M. Negative energy balance influences nutritional quality of milk from Czech Fleckvieh Cows due changes in proportion of fatty acids. Animals. 2020 Mar 27;10(4):563. Go to original source... Go to PubMed...
    15. Ferst JG, Missio D, Bertolin K, Gasperin BG, Leivas FG, Bordignon V, Goncalves PB, Ferreira R. Intrafollicular injection of nonesterified fatty acids impaired dominant follicle growth in cattle. Anim Rep Sci. 2020 Aug 20;219:106536. Go to original source... Go to PubMed...
    16. Fiore F, Spissu N, Sechi S, Cocco R. Evaluation of oxidative stress in dairy cows with left displacement of abomasum. Animals. 2019 Nov 9;9(11):966. Go to original source... Go to PubMed...
    17. Fraser HM, Dickson SE, Lunn SF, Wulff C, Morris KD, Carroll VA, Bicknell R. Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor. Endocrinology. 2000 Mar 1;141(3):995-1000. Go to original source... Go to PubMed...
    18. Grummer RR. Impact of changes in organic nutrient metabolism on feeding the transition dairy cow. J Anim Sci. 1995 Sep 1;73(9):2820-33. Go to original source... Go to PubMed...
    19. Hildebrand C, Hollenbach J, Seeger B, Pfarrer C. β-Hydroxybutyrate effects on bovine caruncular epithelial cells: A model for investigating the peri-implantation period disruption in ketotic dairy cows. Animals. 2023 Sep 18;13(18):2950. Go to original source... Go to PubMed...
    20. Jee H. Size dependent classification of heat shock proteins: A mini-review. J Exerc Rehabil. 2016 Aug 31;12(4):255-9. Go to original source... Go to PubMed...
    21. Jorritsma R, Jorritsma H, Schukken YH, Barlett PC, Wenting T, Wenting GH. Prevalence and indicators of postpartum fatty infiltration of the liver in nine commercial dairy herds in the Netherlands. Liv Prod Sci. 2001 Feb;68(1):53-60. Go to original source...
    22. Karimi N, Seifi HA, Heidarpour M. Assessment of some inflammatory cytokines and immunologic factors in dairy cows with subclinical ketosis. Iran J Vet Sci and Tech. 2021 Dec 11;13(2):29-6.
    23. Kasna E, Zavadilova L, Vareka J, Kyselova J. General resilience in dairy cows: A review. Czech J Anim Sci. 2022 Dec 19;67(12):475-82. Go to original source...
    24. Kasna E, Zavadilova L, Krupova Z, Slosarkova S, Fleischer P. The most common reproductive disorders of cows in Holstein cattle breeding. Czech J Anim Sci. 2023 Nov 30;68(11):433-42. Go to original source...
    25. Kaufman EI, LeBlanc SJ, McBride, BW, Duffield TF, DeVries TJ. Association of rumination time with subclinical ketosis in transition dairy cows. J Dairy Sci. 2016 Apr 28;99(7):5604-18. Go to original source... Go to PubMed...
    26. Kennedy D, Jager R, Mosser DD, Samali A. Regulation of apoptosis by heat shock proteins. IUBMB. 2014 May 26;66(5):327-38. Go to original source... Go to PubMed...
    27. Kristensen TN, Lovendahl P, Berg P, Loeschcke V. Hsp72 is present in plasma from Holstein-Friesian dairy cattle, and the concentration level is repeatable across days and age classes. Cell Stress Chaperones. 2004 Jan 15;9(2):143-9. Go to original source... Go to PubMed...
    28. Leroy JL, Vanholder T, Mateusen B, Christophe A, Opsomer G, de Kruif A, Genicot G, Van Soom A. Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro. Reproduction. 2005 Jun 27;130(4):485-95. Go to original source... Go to PubMed...
    29. Li T, Jin Y, Wu J, Ren Z. Beyond energy provider: Multifunction of lipid droplets in embryonic development. Biol Res. 2023 Jul 12;56(1):38. Go to original source... Go to PubMed...
    30. Lingappan K. NF-κB in oxidative stress. Curr Opin Toxicol. 2018 Feb;7:81-6. Go to original source... Go to PubMed...
    31. Marei WF, Wathes DC, Fouladi-Nashta AA. Impact of linoleic acid on bovine oocyte maturation and embryo development. Reproduction. 2010 Mar 4;139:979-88. Go to original source... Go to PubMed...
    32. Melendez P, Donovan A, Hernandez J. Milk urea nitrogen and infertility in Florida Holstein cows. J Dairy Sci. 2000 Mar 18;83(3):459-63. Go to original source... Go to PubMed...
    33. Melo-Sterza de AF, Poehland R. Lipid metabolism in bovine oocytes and early embryos under in vivo, in vitro, and stress conditions. Int J Mol Sci. 2021 Mar 26;22(7):3421. Go to original source... Go to PubMed...
    34. Meulders B, Marei WFA, Xhonneux I, Bols PEJ, Leroy JLMR. Effect of lipotoxicity on mitochondrial function and epigenetic programming during bovine in vitro embryo production. Sci Rep. 2023 Dec 8;13:21664. Go to original source... Go to PubMed...
    35. Mezzetti M, Minuti A, Piccioli-Cappelli F, Amadori M, Bionaz M, Trevisi E. The role of altered immune function during the dry period in promoting the development of subclinical ketosis in early lactation. J Dairy Sci. 2019 Aug 1;102(10):9241-58. Go to original source... Go to PubMed...
    36. Park HJ, Lee DG, Seong JB, Lee HS, Kwon OS, Kang BS, Park JW, Lee SR, Lee DS. Peroxiredoxin I maintains luteal function by regulating unfolded protein response. Reprod Biol Endocrinol. 2018 Aug 15;16(1):79. Go to original source... Go to PubMed...
    37. Petrovic MZ, Cincovic M, Staric J, Djokovic R, Belic B, Radinovic M, Majkic M, Ilic ZZ. The correlation between extracellular heat shock protein 70 and lipid metabolism in a ruminant model. Metabolites. 2022 Dec 27;12(1):19. Go to original source... Go to PubMed...
    38. Puchalska P, Crawford PA. Metabolic and signaling roles of ketone bodies in health and disease. Annu Rev Nutr. 2021 Oct 11;41:49-77. Go to original source... Go to PubMed...
    39. Rutherford AJ, Oikonomou G, Smith RF. The effect of subclinical ketosis on activity at estrus and reproductive performance in dairy cattle. J Dairy Sci. 2016 Mar 16;99(6):4808-15. Go to original source... Go to PubMed...
    40. Sharma A, Baddela VS, Becker F, Dannenberger D, Viergutz T, Vanselow J. Elevated free fatty acids affect bovine granulosa cell function: A molecular cue for compromised reproduction during negative energy balance. Endocr Connect. 2019 May;8(5):493-505. Go to original source... Go to PubMed...
    41. Shen T, Li X, Loor JJ, Zhu Y, Du X, Wang X, Xing D, Shi Z, Fang Z, Li X, Liu G. Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows. J Dairy Sci. 2019 Sep 5;102(11):10554-63. Go to original source... Go to PubMed...
    42. Shende P, Bhandarkar S, Prabhakar B. Heat shock proteins and their protective roles in stem cell biology. Stem Cell Rev Rep. 2019 Jun 28;15:637-51. Go to original source... Go to PubMed...
    43. Shi M, Sirard MA. Metabolism of fatty acids in follicular cells, oocytes, and blastocysts. Reprod Fertil. 2022 Apr 29;3(2):R96-R108. Go to original source... Go to PubMed...
    44. Stadnik L, Louda F, Jezkova A. The effect of selected factors at insemination on reproduction of Holstein cows. Czech J Anim Sci. 2002 Feb 4;47(5):169-75.
    45. Stadnik L, Bezdicek J, Makarevich A, Kubovicova E, Louda F, Fellnerova I, Hegedusova Z, Holasek R. Ovarian activity and embryo yield in relation to the postpartum period in superovulated dairy cows. Acta Vet Brno. 2017 Feb 17; Go to original source...
    46. 86(1):51-7.
    47. Stadnik L, Duchacek J, Pytlik J, Gasparik M, Codl R, Vrhel M. Cow metabolic status assessed from fat/protein ratio in milk affected ovarian response and number of transferable embryos after superovulation. Czech J Anim Sci. 2022 Jan 24;6;67(2):39-6. Go to original source...
    48. Stadnik L, Kinterova V, Sichtar J, Duchacek J, Gasparik M, Nemcova L, Prochazka R, Codl R. Comparison of selected data acquisition models using on-farm production records on qualitative parameters of oocytes in dairy cows. Czech J Anim Sci. 2024 Jan 16;69(1):1-10. Go to original source...
    49. Steeneveld W, Amuta P, van Soest FJS, Jorritsma R, Hogeveen H. Estimating the combined costs of clinical and subclinical ketosis in dairy cows. PLoS ONE. 2020 Apr 7;15(4):e0230448. Go to original source... Go to PubMed...
    50. Su YQ, Sugiura K, Wigglesworth K, O'Brien MJ, Affourtit JP, Pangas SA, Matzuk MM, Eppig JJ. Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells. Development. 2008 Oct 1;135:111-21. Go to original source... Go to PubMed...
    51. Sun X, Tang Y, Jiang C, Luo S, Jia H, Xu Q, Zhao C, Liang Y, Cao Z, Shao G, Loor JJ, Xu C. Oxidative stress, NF-κB signaling, NLRP3 inflammasome, and caspase apoptotic pathways are activated in mammary gland of ketotic Holstein cows. J Dairy Sci. 2021 Jan;104(1):849-61. Go to original source... Go to PubMed...
    52. Tang Z, Chen J, Zhang Z, Bi J, Xu R, Lin Q, Wang Z. HIF-1α Activation promotes luteolysis by enhancing ROS levels in the corpus luteum of pseudopregnant rats. Oxid Med Cell Longev. 2021 Sep 1;2021:1764929. Go to original source... Go to PubMed...
    53. Vacek M, Stadnik L, Stipkova M. Relationships between the incidence of health disorders and the reproduction traits of Holstein cows in the Czech Republic. Czech J Anim Sci. 2007 May 24;52(8):227-35. Go to original source...
    54. Valm AM, Cohen S, Legant WR, Melunis J, Hershberg U, Wait E, Cohen AR, Davidson MW, Betzig E, Lippincott-Schwartz J. Applying systems-level spectral imaging and analysis to reveal the organelle interactome. Nature. 2017 Jun 1;546(7656):162-7. Go to original source... Go to PubMed...
    55. Vanholder T, Leroy JL, Soom AV, Opsomer G, Maes D, Coryn M, de Kruif A. Effect of non-esterified fatty acids on bovine granulosa cell steroidogenesis and proliferation in vitro. Anim Reprod Sci. 2005 Jun 18;87(1-2):33-44. Go to original source... Go to PubMed...
    56. Vanholder T, Leroy JL, Soom AV, Maes D, Coryn M, Fiers T, de Kruif A. Effect of non-esterified fatty acids on bovine theca cell steroidogenesis and proliferation in vitro. Anim Reprod Sci. 2006 Mar;92(1-2):51-63. Go to original source... Go to PubMed...
    57. Vaidya MM, Singh SV, Dhenge SA, Dongre VB, Gadegaokar GM. Status of plasma heat shock protein-72 in Periparturient dairy cows during thermal and metabolic stress. Livestock Sci. 2023 Aug 25;14:246-50. Go to original source...
    58. Wang Y, Li C, Li J, Wang G, Li L. Non-esterified fatty acid-induced reactive oxygen species mediated granulosa cells apoptosis is regulated by Nrf2/p53 signaling pathway. Antioxidants. 2020 Jun 14;9(6):523. Go to original source... Go to PubMed...
    59. Warzych E, Lipinska P. Energy metabolism of follicular environment during oocyte growth and maturation. J Rep Dev. 2020 Jan 18;66(1):1-7. Go to original source... Go to PubMed...
    60. Yenuganti VR, Viergutz T, Vanselow J. Oleic acid induces specific alterations in the morphology, gene expression and steroid hormone production of cultured bovine granulosa cells. Gen Comp Endocrinol. 2016 Apr 23;232:134-44. Go to original source... Go to PubMed...
    61. Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015 Mar;21(3):263-9. Go to original source... Go to PubMed...
    62. Zarrin M, Wellnitz O, Dorland van HA, Bruckmaier RM. Induced hyperketonemia affects the mammary immune response during lipopolysaccharide challenge in dairy cows. J Dairy Sci. 2014a Nov 18;97(1):330-9. Go to original source... Go to PubMed...
    63. Zarrin M, Wellnitz O, van Dorland HA, Gross JJ, Bruckmaier RM. Hyperketonemia during lipopolysaccharide-induced mastitis affects systemic and local intramammary metabolism in dairy cows. J Dairy Sci. 2014b Mar 28;97(6);3531-41. Go to original source... Go to PubMed...
    64. Zhang G, Burim NA. Ketosis an old story under a new approach. Dairy. 2020 May 10;1(1):42-60. Go to original source...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content