PT  - JOURNAL ARTICLE
AU  - Kourousekos, G.D.
AU  - Theodosiadou, E.K.
AU  - Lymberopoulos, A.G.
AU  - Belibasaki, S.
AU  - Boscos, C.
TI  - Effect of prolonged aflatoxin B&lt;sub&gt;1&lt;/sub&gt; administration on blood serum oestradiol-17β and progesterone concentrations of goats during the anoestrus period --
DP  - 2015 Apr 30
TA  - Czech Journal of Animal Science
PG  - 164--170
VI  - 60
IP  - 4
AID - 10.17221/8130-CJAS
IS  - 12121819
AB  - The effect of prolonged aflatoxin B&lt;sub&gt;1&lt;/sub&gt; (AFB&lt;sub&gt;1&lt;/sub&gt;) administration on blood serum oestradiol-17β and progesterone concentrations in goats during the anoestrus period was investigated. Thirty Greek indigenous goats were used; 10 goats received, per os, 50 μg (treated group T50) and 10 goats received 100 μg (treated group T100) AFB&lt;sub&gt;1&lt;/sub&gt;/day/head, respectively, for 31 days, while 10 goats served as controls (C). Blood samples were collected from each goat twice a week to determine serum oestradiol-17β and progesterone concentrations by radioimmunoassay. Multiple linear regression analysis revealed a significant (P &amp;lt; 0.05) positive dependence of blood serum oestradiol-17β concentration over group (C = 0, T50 = 50, T100 = 100), in a dose-dependent manner, and a significant (P &amp;lt; 0.05) negative dependence over time (0-31 days, from the onset to the end of AFB&lt;sub&gt;1&lt;/sub&gt; administration). Linear regression analysis revealed a significant (P &amp;lt; 0.05) positive dependence of blood serum progesterone concentration over group (C = 0, T50 = 50, T100 = 100), in a dose-dependent manner. Pearson's correlation coefficient revealed a significant (P &amp;lt; 0.05) positive correlation between blood serum oestradiol-17β and progesterone concentration, but only in the goats of the control group. In conclusion, the prolonged administration of 100 or even of 50 μg AFB&lt;sub&gt;1&lt;/sub&gt;/day/head during the anoestrus period, increased blood serum oestradiol-17β and progesterone concentrations of goats, in a dose-dependent manner, and in the treated groups disturbed the positive correlation between oestradiol-17β and progesterone concentration shown in the goats of the control group.